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Prograf (tacrolimus) can be prescribed to affect the defense mechanism of the immune system in order to prevent transplant rejection. This drug can be combined with other medicines as directed by your doctor to prevent rejection of heart, kidney or liver transplants. Before you start taking this medicine you need to be examined by your doctor and talk about potential risks. Patients taking Prograf for a long time have been reported to develop cancer and diabetes. The dose you have been prescribed is based on your current health condition and other medicines you are taking. Make sure you take the exact dose prescribed to benefit from the treatment and avoid unpleasant side effects.

Some of the mild side effects you may experience when taking this medicine include insomnia, mild skin rash, itching, nausea, swelling in the hands or feet, stomach pain and loss of appetite. Prograf can increase your skin sensitivity. Make sure you wear protective clothing when exposed to direct sunlight. Grapefruit juice can make Prograf less efficient and cause serious side effects. Discuss your diet with your doctor and make sure you exclude grapefruit juice or any products containing it.